Folate is essential for the de novo biosynthesis of purines and thymidylate, and is an
important mediator in the transfer of methyl groups for DNA methylation. Folate deficiency …

One of the most important criteria for successful generation of a therapeutic protein from a
recombinant cell is to obtain a cell line that maintains stability of production. If this is not …

Dosage compensation for X-linked genes in mammals is accomplished by inactivating one
of the two X chromosomes in females. X-chromosome inactivation (XCI) occurs during …

Studies in adrenocortical cells have implicated the orphan nuclear receptor SF-1 in the gene
regulation of the steroid hydroxylases. We used targeted disruption of the Ftz-F1 gene …

New Findings What is the topic of this review? This review outlines the history of research on
epigenetic adaptations to heat exposure. The perspective taken is that adaptations reflect …

One of the most prevalent products of oxygen radical injury in DNA is 8-hydroxyguanosine.
Cells must be able to withstand damage by oxygen radicals and possess specific repair …

Preimplantation mouse embryos contain very high levels of DNA methyltransferase activity.
We show here that the form of DNA methyltransferase (DNA MTase) in early embryos differs …

Silencing of tumor-suppressor genes by hypermethylation of promoter CpG islands is well
documented in human cancer and may be mediated by methyl-CpG-binding proteins, like …

Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

Background. Global DNA hypomethylation has been observed in some human neoplasms
and has been implicated as an important factor in carcinogenesis. The current study was …