Epigenetic modifications determine phenotypic characteristics in a reversible, stable and
genotype-independent manner. Epigenetic modifications mainly encompass CpG island …

In higher organisms, all cells share the same genome, but every cell expresses only a
limited and specific set of genes that defines the cell type. During cell division, not only the …

The Mll gene is a member of the mammalian trithorax group, involved with the antagonistic
Polycomb group in epigenetic regulation of homeotic genes. MLL contains a highly …

The CcrM adenine DNA methyltransferase, which specifically modifies GANTC sequences,
is necessary for viability in Caulobacter crescentus. To our knowledge, this is the first …

Interleukin (IL)-1β is a pleiotropic cytokine implicated in a variety of activities, including
damage of insulin-producing cells, brain injury, or neuromodulatory responses. Many of …

Osteosarcoma is a common malignant bone tumor with a propensity to metastasize to the
lungs. Epigenetic abnormalities have been demonstrated to underlie osteosarcoma …

BACKGROUND The global DNA methylation of 136 breast lesions (117 primary invasive
carcinomas, 5 benign phyllodes tumors, 11 fibroadenomas, and 3 sclerosing adenosis) and …

Epigenetic approaches for estimating the age of living organisms are revolutionizing studies
of long‐lived species. Molecular biomarkers that allow age estimates from small tissue …

Previously it has been found that binding of the Sp1 transcription factor is not significantly
affected by methylation of the CpG dinucleotide within its binding site, 5′-GGGCGG (lower …

The fragile X syndrome is commonly associated with mutant alleles of the FMR7 gene that
are hypermethylated and have large expansions of CGG repeats. We present data here on …