Stress, a common if unpredictable life event, can have pronounced effects on physiology
and behavior. Individuals show wide variation in stress susceptibility and resilience, which …

Dynamic regulation of chromatin structure in postmitotic neurons plays an important role in
learning and memory. Methylation of cytosine nucleotides has historically been considered …

Maternal infection during pregnancy increases the risk of neurodevelopmental disorders in
the offspring. In addition to its influence on other neuronal systems, this early-life …

The significant consequences of ethanol use during pregnancy are neurobehavioral
abnormalities involving hippocampal and neocortex malfunctions that cause learning and …

Alcohol consumption during pregnancy and its damaging consequences on the developing
infant brain are significant public health, social, and economic issues. The major distinctive …

Selective serotonin reuptake inhibitor (SSRI) antidepressants are the mainstay treatment for
the 10–20% of pregnant and postpartum women who suffer major depression, but the effects …

Depression is one of the most common psychiatric disorders affecting public health. Studies
over the past years suggest that the methylations of some specific genes such as BDNF …

DNA methyltransferases (DNMTs) are widely expressed in the brain, dictating the
transcriptional activity of genes through various epigenetic mechanisms. Functional …

Epigenetic processes regulate gene expression independent of the DNA sequence and are
increasingly being investigated as contributors to the development of behavioral disorders …

Background Early life stress is thought to contribute to psychiatric disorders, but the precise
mechanisms underlying this link are poorly understood. As neonatal stress decreases adult …