Macrophage polarization in chronic lymphocytic leukemia: Nurse-like cells are the caretakers of leukemic cells

O Mesaros, L Jimbu, A Neaga, C Popescu, I Berceanu… - Biomedicines, 2020 - mdpi.com
Macrophages are terminally differentiated innate immune cells. Through their activation,
they can be polarized towards the pro-inflammatory M1 type or the wound healing …

Immunomodulatory drugs activate NK cells via both Zap-70 and cereblon-dependent pathways

T Hideshima, D Ogiya, J Liu, T Harada, K Kurata, J Bae… - Leukemia, 2021 - nature.com
Immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide show remarkable
antitumor activity in multiple myeloma (MM) via directly inhibiting MM-cell growth in the bone …

Unraveling the mystery: How bad is BAG3 in hematological malignancies?

Q Liu, J Liu, X Huang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
BAG3, also known as BIS and CAIR-1, interacts with Hsp70 via its BAG domain and with
other molecules through its WW domain, PXXP repeats and IPV motifs. BAG3 can participate …

ZAP70 interaction with 13 mRNAs as a potential immunotherapeutic target for endometrial cancer

Y Zhang, H Lu, Y Yu - Oncology Letters, 2023 - spandidos-publications.com
For advanced, refractory endometrial cancer (EC), it is advisable to find effective
immunotherapeutic targets. In the present study, genes affecting the immune status of …

Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia

X Alimu, J Zhang, N Pang, R Zhang… - Immunity …, 2023 - Wiley Online Library
Background Galectin‐9 and myeloid‐derived suppressor cells (MDSCs) have an important
role in tumors, but their clinical values in chronic lymphocytic leukemia (CLL) have not been …

Prognostic Potential of Galectin-9 mRNA Expression in Chronic Lymphocytic Leukemia

A Bojarska-Junak, W Kowalska, S Chocholska… - Cancers, 2023 - mdpi.com
Simple Summary There are still very few studies on Galectin-9 (Gal-9) in chronic lymphocytic
leukemia (CLL), and the effect of Gal-9 on CLL pathogenesis. This study considers the …

[PDF][PDF] Mining of transcriptome identifies CD109 and LRP12 as possible biomarkers and deregulation mechanism of T cell receptor pathway in Acute Myeloid …

ENSGD Shyl, B Malgija, AM Iniyan, R Mahendran… - Heliyon, 2022 - cell.com
Abstract Acute Myeloid Leukemia (AML) is a heterogeneous disease with highest mortality
compared to other types of leukemia. There is a need to find the gene abnormalities and …

Clinical and prognostic significance of cell sensitivity to chemotherapy detected in vitro on treatment response and survival of leukemia patients

M Kolesnikova, A Sen'kova, S Tairova… - Journal of personalized …, 2019 - mdpi.com
Multidrug resistance (MDR) is a major challenge in leukemia treatment. The objective of this
study was to identity predictors of MDR to allow for rapid and economical assessment of the …

Advances in Monitoring and Prognostication for Lymphoma by Flow Cytometry

AP Singh, EL Courville - Clinics in Laboratory Medicine, 2023 - labmed.theclinics.com
Lymphomas comprise a heterogeneous group of diseases with variable clinical
presentations, pathological features, and prognoses. In lymphoma diagnosis, flow cytometry …

A new method for screening acute/chronic lymphocytic leukemia: dual-label time-resolved fluorescence immunoassay

Z Zhang, J Zhang, S Dai, H Xu - BMC biotechnology, 2022 - Springer
Background Lymphocytic leukemia (LL) is a primary malignant tumor of hematopoietic
tissue, which seriously affects the health of children and the elderly. The study aims to …