Melatonin is uncommonly effective in reducing oxidative stress under a remarkably large
number of circumstances. It achieves this action via a variety of means: direct detoxification …

Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus
(SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …

COVID-19 pandemic has a high mortality rate and is affecting practically the entire world
population. The leading cause of death is severe acute respiratory syndrome as a …

Sepsis is one of the most important causes of death in intensive care units. Despite the fact
that sepsis pathogenesis remains obscure, there is increasing evidence that oxidants and …

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the
immune system. Despite the large number of reports implicating melatonin as an …

Melatonin is the major secretory product synthesized and secreted by the pineal gland and
shows both a wide distribution within phylogenetically distant organisms from bacteria to …

Classically, mitochondria have largely been believed to influence the development of illness
by modulating cell metabolism and determining the rate of production of high-energy …

Nowadays, melatonin, previously considered only as a pharmaceutical product for rhythm
regulation and sleep aiding, has shown its potential as a co‐adjuvant treatment in intestinal …

Numerous pharmaceutical drugs have been repurposed for use as treatments for COVID-19
disease. These drugs have not consistently demonstrated high efficacy in preventing or …