Clinical observations have shown that patients with chronic neuropathic pain or itch exhibit
symptoms of increased anxiety, depression and cognitive impairment. Such patients need …

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a painful condition,
experienced by patients undergoing chemotherapy with some specific drugs, such as …

Highlights•Intrathecal injection DAPT suppressed Notch signaling and relieved vincristine-
induced neuropathic pain.•Inactivated Notch signaling could suppress microglial …

Cancer is a common disease threatening human health, chemotherapy is widely used in
clinical treatment of cancer, but chemotherapy-induced peripheral neuropathy (CIPN) has a …

(1) Background: Milnacipran is a typical serotonin–norepinephrine reuptake inhibitor and
has been shown to have analgesic effects in several pain models. However, its …

Background In animal research, authorities require a classification of anticipated pain levels
and a perioperative analgesia protocol prior to approval of the experiments. However, data …

Neuropathic pain is a chronic and sometimes intractable condition caused by lesions or
diseases of the somatosensory nervous system. Many drugs are available but unfortunately …