Multiple functions of m6A RNA methylation in cancer

Y Pan, P Ma, Y Liu, W Li, Y Shu - Journal of hematology & oncology, 2018 - Springer
First identified in 1974, m 6 A RNA methylation, which serves as a predominant internal
modification of RNA in higher eukaryotes, has gained prodigious interest in recent years …

The immune system in cancer pathogenesis: potential therapeutic approaches

PH Pandya, ME Murray, KE Pollok… - Journal of …, 2016 - Wiley Online Library
Interplay among immune activation and cancer pathogenesis provides the framework for a
novel subspecialty known as immunooncology. In the rapidly evolving field of …

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

J Han, J Wang, X Yang, H Yu, R Zhou, HC Lu… - Molecular cancer, 2019 - Springer
Background METTL3 is known to be involved in all stages in the life cycle of RNA. It affects
the tumor formation by the regulation the m6A modification in the mRNAs of critical …

Combinatorial epigenetics impact of polyphenols and phytochemicals in cancer prevention and therapy

I Arora, M Sharma, TO Tollefsbol - International journal of molecular …, 2019 - mdpi.com
Polyphenols are potent micronutrients that can be found in large quantities in various food
sources and spices. These compounds, also known as phenolics due to their phenolic …

m6A methylation regulates osteoblastic differentiation and bone remodeling

M Huang, S Xu, L Liu, M Zhang, J Guo… - Frontiers in cell and …, 2021 - frontiersin.org
Osteoporosis is a prevalent bone disease of the aging population, which is characterized by
a decrease in bone mass because of the imbalance of bone metabolism. Although the …

Mechanisms underlying biological effects of cruciferous glucosinolate-derived isothiocyanates/indoles: a focus on metabolic syndrome

M Esteve - Frontiers in Nutrition, 2020 - frontiersin.org
An inverse correlation between vegetable consumption and the incidence of cancer has
long been described. This protective effect is stronger when cruciferous vegetables are …

The role of isothiocyanates as cancer chemo-preventive, chemo-therapeutic and anti-melanoma agents

M Mitsiogianni, G Koutsidis, N Mavroudis, DT Trafalis… - Antioxidants, 2019 - mdpi.com
Many studies have shown evidence in support of the beneficial effects of phytochemicals in
preventing chronic diseases, including cancer. Among such phytochemicals, sulphur …

The role of the extracellular matrix protein TGFBI in cancer

A Corona, GC Blobe - Cellular signalling, 2021 - Elsevier
The secreted extracellular protein, transforming growth factor beta induced (TGFBI or
βIGH3), has roles in regulating numerous biological functions, including cell adhesion and …

Recent progress in DNA methyltransferase inhibitors as anticancer agents

Z Zhang, G Wang, Y Li, D Lei, J Xiang… - Frontiers in …, 2022 - frontiersin.org
DNA methylation mediated by DNA methyltransferase is an important epigenetic process
that regulates gene expression in mammals, which plays a key role in silencing certain …

(-)-Epigallocatechin-3-gallate reverses the expression of various tumor-suppressor genes by inhibiting DNA methyltransferases and histone deacetylases in human …

MA Khan, A Hussain, MK Sundaram… - Oncology …, 2015 - spandidos-publications.com
There has been increasing evidence that numerous bioactive dietary agents can hamper the
process of carcinogenesis by targeting epigenetic alterations including DNA methylation …