The mitochondrial DNA (mtDNA) m. 3243A> G mutation is one of the most common
pathogenic mtDNA variants, showing complex genetics, pathogenic molecular mechanisms …

BACKGROUND The use of nuclear transfer (NT) has been proposed as a novel
reproductive treatment to overcome the transmission of maternally-inherited mitochondrial …

While the fertilized egg inherits its nuclear DNA from both parents, the mitochondrial DNA is
strictly maternally inherited. Cells contain multiple copies of mtDNA, each of which encodes …

The developmental potential of early embryos is mainly dictated by the quality of the oocyte.
Here, we explore the utility of the maternal spindle transfer (MST) technique as a …

Purpose Providing additional insights on the efficacy of human nuclear transfer (NT). Here,
and earlier, NT has been applied to minimize transmission risk of mitochondrial DNA …

Prevention of mitochondrial DNA (mtDNA) diseases may currently be possible using
germline nuclear transfer (NT). However, scientific evidence to compare efficiency of …

Objective To study whether embryo biopsy for preimplantation genetic diagnosis/
preimplantation genetic screening (PGD/PGS) can influence pregnancy complications and …

To evaluate and compare mitochondrial DNA (mtDNA) carry-over and embryonic
development potential between different nuclear transfer techniques we performed germinal …

Mitochondrial diseases require customized approaches for reproductive counseling,
addressing differences in recurrence risks and reproductive options. The majority of …

Mitochondria are the largest generator of ATP in the cell. It is therefore expected that energy‐
requiring processes such as oocyte maturation, early embryonic or fetal development, would …