Abdominal aortic aneurysm (AAA), a deadly vascular disease in human, is a chronic
degenerative process of the abdominal aorta. In this process, inflammatory responses and …

Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection
was originally described by Erdheim as a noninflammatory lesion related to the loss of …

Notch signaling is an evolutionarily conserved pathway, which is fundamental for the
development of all tissues, organs and systems of human body. Recently, a considerable …

Bicuspid aortic valve (BAV) is frequently associated with the development of ascending
aortic aneurysm, even if the underlying mechanisms remain to be clarified. Here, we …

Recent advances in the field of innate immunity have revealed a complex role of innate
immune signaling pathways in both tissue homeostasis and disease. Among them, the Toll …

Preclinical and clinical studies suggest that specific subsets of cells isolated from the
peripheral blood, play an essential role in the imbalance of damage and repair during age …

Objectives Functional and quantitative alterations and senescence of circulating and
expanded endothelial progenitor cells (EPC), as well as systemic and tissue modifications of …

Hyperhomocysteinemia (HHcy) has been observed to promote hypertension, but the
mechanisms are unclear. Toll-like receptor 4 (TLR-4) is a cellular membrane protein that is …

Aims Overactivated B cells secrete pathological antibodies, which in turn accelerate the
formation of abdominal aortic aneurysms (AAAs). Hyperhomocysteinaemia (HHcy) …

Background Acute aortic dissection (AAD) is an event which may be rapidly fatal without
early diagnosis and treatment. Aging is one of the main risk factors that could leading to …