In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and
biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through …

As one of the most abundant and well-studied epigenetic modifications, DNA methylation
plays an essential role in normal development and cellular biology. Global alterations to the …

Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced
algorithms to identify drivers now exist, but systematic attempts to combine and optimize …

DNA is vulnerable to damage resulting from endogenous metabolites, environmental and
dietary carcinogens, some anti-inflammatory drugs, and genotoxic cancer therapeutics …

DNA-demethylating agents have shown clinical anti-tumor efficacy via an unknown
mechanism of action. Using a combination of experimental and bioinformatics analyses in …

We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays
of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited …

Effective anticancer immunotherapy treatments constitute a qualitative leap in cancer
management. Nonetheless, not all patients benefit from such therapies because they fail to …

Features of the cancer epigenome distinguish cancers from their respective cell of origin and
establish therapeutic vulnerabilities that can be exploited through pharmacologic inhibition …

The translational challenges in the field of precision oncology are in part related to the
biological complexity and diversity of this disease. Technological advances in genomics …

The development of diagnostic and therapeutic nanoparticles for biomedical applications is
of broad current interest in science, engineering, and medicine. The fundamental basis is …