The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million
people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is …

Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of
NO synthase (NOS; EC 1.14. 13.39). They all utilize l-arginine and molecular oxygen as …

Endothelial NOS (eNOS), and its product NO, are vital components of the control of
vasomotor function and cardiovascular homeostasis. In the present review, we will take a …

Background Wound healing is impaired in diabetes mellitus, but the mechanisms involved in
this process are virtually unknown. Proteins belonging to the insulin signaling pathway …

Vascular pathology is a major feature of Alzheimer's disease (AD) and other dementias. We
recently showed that chronic administration of the target-of-rapamycin (TOR) inhibitor …

Formation of NO by endothelial NOS (eNOS) is a central process in the homeostatic
regulation of vascular functions including blood pressure regulation, and fluid shear stress …

The PI3K/Akt pathway is necessary for several key endothelial cell (EC) functions, including
cell growth, migration, survival, and vascular tone. However, existing literature supports the …

The specific role of VEGFA-induced permeability and vascular leakage in physiology and
pathology has remained unclear. Here we show that VEGFA-induced vascular leakage …

Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by
loss-of-function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …

Transient disruption of endothelial adherens junctions and cytoskeletal remodeling are
responsible for increases in vascular permeability induced by inflammatory stimuli and …