The dynamics of the blood oxygenation level‐dependent (BOLD) response are dependent
on changes in cerebral blood flow, cerebral blood volume and the cerebral metabolic rate of …

The BOLD contrast mechanism has a complex relationship with functional brain activity,
oxygen metabolism, and neurovascular factors. Accurate interpretation of the BOLD signal …

Functional magnetic resonance imaging typically measures signal increases arising from
changes in the transverse relaxation rate over small regions of the brain and associates …

Cerebral metabolic rate of oxygen (CMRO2) is an important index of tissue viability and
brain function, but this parameter cannot yet be measured routinely on clinical scanners …

We have recently described an extension of calibrated MRI, which we term QUO2 (for
QUantitative O2 imaging), providing absolute quantification of resting oxidative metabolism …

Calibrated BOLD fMRI is a promising alternative to the classic BOLD contrast due to its
reduced venous sensitivity and greater physiological specificity. The delayed adoption of …

Magnetic resonance imaging (MRI) is the currently most versatile imaging technique in the
medical environment (Lauterbur, 1973). Whereas the main application is based on imaging …

Abstract (EN) This thesis describes the development, implementation and application of
various quantitative functional magnetic resonance imaging (fMRI) approaches at ultra-high …

Functional MRI (fMRI) studies using the BOLD signal are done under the general
assumption that the BOLD signal can be used as a direct index of neuronal activation …