Osteosarcoma is the most common primary malignant bone tumor and is associated with a
high risk of recurrence and distant metastasis. Effective treatment for osteosarcoma …

Migrasomes are newly discovered extracellular vesicles (EVs) that are formed in migrating
cells and mediate intercellular communication. However, their size, biological generation …

The aim of this paper was to design and fabricate a novel composite scaffold based on the
combination of 3D-printed polylactic acid-based triply periodic minimal surfaces (TPMSs) …

In osteosarcoma, immunotherapy often faces hurdles posed by cancer‐associated
fibroblasts (CAFs) that secrete dense extracellular matrix components and cytokines …

Osteosarcoma (OS) is the primary malignant bone tumor. Despite therapeutic strategies
including surgery, chemotherapy, and radiotherapy have been introduced into the war of …

Tumor evolution is the accumulation of various tumor cell behaviors from tumorigenesis to
tumor metastasis and is regulated by the tumor microenvironment (TME). However, the …

Current in vitro models for osteosarcoma investigation and drug screening, including two-
dimensional (2D) cell culture and tumour spheroids (ie cancer stem-like cells), lack …

Osteosarcoma is the most common bone tumor that leads to high mortality in adolescents
and children. The tRNA N7-methylguanosine methyltransferase METTL1 is located in …

Additive manufacturing (AM) has emerged as a disruptive technique within healthcare
because of its ability to provide personalized devices; however, printed metal parts still …

Osteosarcoma (OS) is the most common type of bone sarcoma. Despite the availability of
multimodal treatment with surgery and chemotherapy, the clinical results remain …