Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Although at the genetic level cancer is caused by diverse mutations, epigenetic
modifications are characteristic of all cancers, from apparently normal precursor tissue to …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

Cell-cycle transitions in higher eukaryotes are regulated by different cyclin-dependent
kinases (CDKs) and their activating cyclin subunits. Based on pioneering findings that a …

A striking link exists between advanced age and increased incidence of cancer. Here I
review how several of the age-related molecular and physiological changes might act in …

Innate and adaptive immunity are the major defence mechanisms of higher organisms
against inherent and environmental threats. Innate immunity is present already in unicellular …

Colon cancer has been viewed as the result of progressive accumulation of genetic and
epigenetic abnormalities. However, this view does not fully reflect the molecular …

CpG island hypermethylation is a mechanism of gene silencing that can be usurped by
neoplastic cells to inactivate undesirable genes. In the colon, hypermethylation often starts …

Endometriosis is a common gynecologic disorder with an enigmatic etiopathogenesis.
Although it has been proposed that endometriosis is a hormonal disease, an autoimmune …

The regulation of gene transcription is not simply dependent on the presence or absence of
DNA-binding transcription factors that turn genes on or off, but also involves processes …