The kynurenine pathway: a finger in every pie

J Savitz - Molecular psychiatry, 2020 - nature.com
The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …

[HTML][HTML] Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …

G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

[HTML][HTML] High cortisol and the risk of dementia and Alzheimer's disease: a review of the literature

S Ouanes, J Popp - Frontiers in aging neuroscience, 2019 - frontiersin.org
Introduction: Cortisol effects on the brain are exerted through two distinct receptors, inducing
complex and even opposite effects on the cerebral structures implicated in the various …

Depression in neurodegenerative diseases: Common mechanisms and current treatment options

CPC Galts, LEB Bettio, DC Jewett, CC Yang… - Neuroscience & …, 2019 - Elsevier
Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Depression, dementia and immune dysregulation

S Hayley, AM Hakim, PR Albert - Brain, 2021 - academic.oup.com
Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

Adult hippocampal neurogenesis in major depressive disorder and Alzheimer's disease

T Berger, H Lee, AH Young, D Aarsland… - Trends in molecular …, 2020 - cell.com
Depression and dementia are major public health problems. Major depressive disorder
(MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No …

Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis

S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - Brain, 2023 - academic.oup.com
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …

[HTML][HTML] The relationship between stress and Alzheimer's disease

NJ Justice - Neurobiology of stress, 2018 - Elsevier
Stress is critically involved in the development and progression of disease. From the stress
of undergoing treatments to facing your own mortality, the physiological processes that …

A systematic review of yoga for major depressive disorder

H Cramer, D Anheyer, R Lauche, G Dobos - Journal of Affective Disorders, 2017 - Elsevier
Background The purpose of this review was to investigate the efficacy and safety of yoga
interventions in treating patients with major depressive disorder. Methods MEDLINE …

[HTML][HTML] Pathways connecting late-life depression and dementia

C Linnemann, UE Lang - Frontiers in pharmacology, 2020 - frontiersin.org
Late-life depression is associated with significant cognitive impairment. Meta-analyses
showed that depression is associated with an increased risk for Alzheimer's disease (AD) …