Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses
considerable therapeutic challenges. Recent genetic and technological advances have …

Alterations in the epigenome and metabolism affect molecular rewiring of cancer cells
facilitating cancer development and progression. Modulation of histone and DNA …

Histone lysine methyltransferases (HMTs), a large class of enzymes that catalyze site-
specific methylation of lysine residues on histones and other proteins, play critical roles in …

Aberrant DNA methylation is a critically important modification in cancer cells, which,
through promoter and enhancer DNA methylation changes, use this mechanism to activate …

Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to
cancer progression and metastasis. It is now well understood that both losses and gains of …

Innate and acquired resistance towards the conventional therapeutic regimen imposes a
significant challenge for the successful management of cancer for decades. In patients with …

A small subpopulation of cells within the bulk of tumors share features with somatic stem
cells, in that, they are capable of self-renewal, they differentiate, and are highly resistant to …

The comparison of DNA methylation patterns across cancer types (pan-cancer methylome
analyses) has revealed distinct subgroups of tumors that share similar methylation patterns …

Recent studies have demonstrated that the DNA methylome changes with age. This
epigenetic drift may have deep implications for cellular differentiation and disease …

Systematically investigating the scores of genes mutated in cancer and discerning disease
drivers from inconsequential bystanders is a prerequisite for precision medicine but remains …