Abstract Fibroblast growth factor 21 (FGF21) plays an important role in regulating glucose
and lipid metabolism, but its role in cancer is less well-studied. We aimed to investigate the …

The majority of kidney cancers are associated with mutations in the von Hippel-Lindau gene
and a small proportion are associated with infrequent mutations in other well characterized …

The epigenome is a heritable layer of information not encoded in the DNA sequence of the
genome, but in chemical modifications of DNA or histones. These chemical modifications …

N-glycan, a fundamental and versatile protein modification in mammals, plays critical roles
in various physiological and pathological events including cancer progression. The …

Abstract Background and Aims: Lung cancer is the leading cause of cancer death
worldwide. Cigarette smoking is the well‐known risk factor for lung cancer. Epidemiological …

Prostate cancer is driven by a combination of genetic and/or epigenetic alterations.
Epigenetic alterations are frequently observed in all human cancers, yet how aberrant …

Bromodomain protein 4 (BRD4) is a member of the bromodomain and extra-terminal domain
(BET) protein family. It binds to acetylated histone tails via its tandem bromodomains BD1 …

Mutations in chromatin modifier genes are frequently associated with neurodevelopmental
diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 …

Protein lysine methyltransferases (PKMTs) regulate diverse physiological processes
including transcription and the maintenance of genomic integrity. Genetic studies suggest …

Tumor classification has evolved over the last decades with technical progress contributing
much to our current concepts. Among diagnostic hallmarks, novelties were immunostaining …