Neuroblastoma is a solid, neuroendocrine tumor with divergent clinical behavior ranging
from asymptomatic to fatal. The diverse clinical presentations of neuroblastoma are directly …

Neuroblastoma derived from primitive cells of the sympathetic nervous system typically
develops in the adrenal medulla or paraspinal ganglia. Neuroblastoma usually occurs …

Extracellular vesicles (EVs) are membrane enclosures released by eukaryotic cells that
carry bioactive molecules and serve to modulate biological responses in recipient cells. Both …

Adverse prognosis in Ewing sarcoma (ES) is associated with the presence of metastases,
particularly in bone, tumor hypoxia and chromosomal instability (CIN). Yet, a mechanistic …

Although most cell membrane proteins are modified by glycosylation, our understanding of
the role and actions of protein glycosylation is still very limited. β1, 3galactosyltransferase …

The biological and clinical heterogeneity of neuroblastoma (NB) demands novel biomarkers
and therapeutic targets in order to drive the most appropriate treatment for each patient …

There is a high demand for a non-invasive, rapid, and highly accurate tool for disease
diagnostics. Recently, saliva based diagnostics for the detection of specific biomarkers has …

Chronic obstructive pulmonary disease (COPD) is a risk factor for lung cancer development.
COPD induces activation of hypoxia-induced signaling, causing remodeling of surrounding …

Background Neuroblastoma (NB) is the most common extracranial solid tumor of childhood,
and high-risk disease is resistant to intensive treatment. Histotripsy is a focused ultrasound …

Background Neuroblastoma is a paediatric cancer that despite multimodal therapy still has a
poor outcome for many patients with high risk tumours. Retinoic acid (RA) promotes …