Integrins are considered the main cell-adhesion transmembrane receptors that play
multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in …

In autosomal dominant polycystic kidney disease (ADPKD), the inexorable growth of
numerous fluid-filled cysts leads to massively enlarged kidneys, renal interstitial damage …

Background Fibrosis is a major cause of loss of renal function in autosomal dominant
polycystic kidney disease (ADPKD). In this study, we examined whether vasopressin type-2 …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the presence of
numerous fluid-filled cysts, extensive fibrosis, and the progressive decline in kidney function …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive
enlargement of fluid-filled cysts, causing nephron loss and a decline in renal function …

Renal fibrosis is an important component of chronic kidney disease, an incurable pathology
with increasing prevalence worldwide. With a lack of available therapeutic options, end …

Loss of estrogen as a result of aging, pelvic cancer therapy, genetics, or eating disorders
affects numerous body systems including the reproductive tract. Specifically, a chronic …

The most common form of polycystic kidney disease (PKD) in humans is caused by
mutations in the PKD1 gene coding for polycystin1 (PC1). Among the many identified or …

Periostin is a matricellular protein that is expressed in several tissues during embryonic
development; however, its expression in adults is mostly restricted to collagen-rich …

Kidney fibrosis is a common outcome of a wide variety of chronic kidney diseases, in which
virtually all kinds of renal resident and infiltrating cells are involved. As such, well …