Background: Cardiovascular (CV) diseases remain a leading and costly cause of death
globally. Patients with previous CV events are at high risk of recurrence. Secondary …

Polypill is a multi-drug formulation in a single pill intended to simplify the drug regimen and
reduce medication-induced adverse effects. The most common multidrug combinations in a …

Background Fixed-dose combination treatments reduce cardiovascular disease in primary
prevention. We aim to explore whether those benefits differ in the presence of CKD. Methods …

Background Higher medication adherence reduces the risk of new cardiovascular events.
However, there are individual and health system barriers that lead to lower adherence. The …

Background Fixed‐dose combination (FDC) antihypertensive products improve blood
pressure control and adherence among patients with hypertension. It is unknown to what …

Fixed-dose combination (FDC) therapy, also known as polypill therapy, targets risk factors
for atherosclerotic cardiovascular disease (ASCVD) and has been proposed as a strategy to …

Introduction This study assessed the real-life effectiveness of a single-pill combination (SPC)
of bisoprolol/perindopril for controlling blood pressure (BP) and symptoms of angina in …

Aims We aimed to perform a systematic review and meta-analysis of randomized controlled
trials (RCTs) to determine the impact of a polypill-based strategy (PBS) on therapeutic …

Although the cardiovascular (CV) polypill concept is not new and several guidelines state
that a CV polypill should be considered an integral part of a comprehensive CV disease …

A polypill strategy has been demonstrated to improve treatment adherence in several
cardiovascular disease (CVD) settings. However, data on the prognostic impact in the …