Chiral substances possess a unique architecture such that, despite sharing identical
molecular formulas, atom-to-atom linkages, and bonding distances, they cannot be …

This article focuses on local protein synthesis as a basis for maintaining axoplasmic mass,
and expression of plasticity in axons and terminals. Recent evidence of discrete ribosomal …

Colchicine, present as a major alkaloid in Colchicum autumnale, is an old drug used in
medicine in acute gout attacks and in Famililal Mediterranean Fever (FMF). Colchicine and …

The nicotinic acetylcholine receptor (AChR) presents two very well differentiated domains for
ligand binding that account for different cholinergic properties. In the hydrophilic …

Publisher Summary This chapter describes the structures of the alkaloids, synthesis of
alkaloids, and pharmacology of alkaloids of the Calabar bean (Physostigmu uenenosum) …

The acute toxicity of organophosphorus (OP) compounds in mammals is due to their
irreversible inhibition of acetylcholinesterase (AChE) in the nervous system, which leads to …

A major pathological hallmark of Alzheimer disease (AD) is the appearance in the brain of
senile plaques that are primarily composed of aggregated forms of β-amyloid peptide (Aβ) …

A concise, highly efficient formal total synthesis of dl-physostigmine is described, using a
relatively simple method that should be adaptable to the synthesis of homologous members …

Background Carbamates physostigmine and pyridostigmine have been used as a
pretreatment against poisoning with nerve agents in order to reversibly inhibit and thus …

Pretreatment of nonhuman primates with physostigmine (Phy) and scopolamine or
physostigmine and trihexyphenidyl 25 min before exposure to 2 LD50 soman im resulted in …