Genetic predisposition and risk factors such as hypertension and smoking can instigate the
development of thoracic aortic aneurysm (TAA), which can lead to highly lethal aortic wall …

As essential components of our connective tissues, elastic fibres give tissues such as major
blood vessels, skin and the lungs their elasticity. Their formation is complex and co …

Abdominal aortic aneurysm (AAA) is a chronic vascular disease caused by localized
weakening and broadening of the abdominal aorta. AAA is a clearly underdiagnosed …

Aim Thoracic aortic aneurysms are a life-threatening condition often diagnosed too late. To
discover novel robust biomarkers, we aimed to better understand the molecular mechanisms …

Transforming growth factor (TGF)-β is a multifunctional peptide growth factor that has a vital
role in the regulation of cell growth, differentiation, inflammation, and repair in a variety of …

Thoracic aortic aneurysms (TAAs) are permanent pathological dilatations of the thoracic
aorta, which can lead to life-threatening complications, such as aortic dissection and rupture …

Transforming growth factor-beta 2 (TGF-β2), an important member of the TGF-β family, is a
secreted protein that is involved in many biological processes, such as cell growth …

Objective: A cardinal feature of Marfan syndrome is thoracic aortic aneurysm. The
contribution of the renin-angiotensin system via AT1aR (Ang II [angiotensin II] receptor type …

Aortic aneurysms (AAs) are dilations of the aorta, that are often fatal upon rupture.
Diagnostic radiological techniques such as ultrasound (US), magnetic resonance imaging …

Bicuspid aortic valve (BAV) is the most common type of congenital cardiac malformation.
Patients with a BAV have a predisposition for the development of thoracic aortic aneurysm …