High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer
F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …
agent when administered intravenously and in high doses (high-dose IVC). Early phase …
Two faces of vitamin C—antioxidative and pro-oxidative agent
J Kaźmierczak-Barańska, K Boguszewska… - Nutrients, 2020 - mdpi.com
Vitamin C has been known for decades. It is common in everyday use as an element of the
diet, supplementation, and a preservative. For years, research has been conducted to …
diet, supplementation, and a preservative. For years, research has been conducted to …
[HTML][HTML] Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach
C Glorieux, PB Calderon - Biological chemistry, 2017 - degruyter.com
This review is centered on the antioxidant enzyme catalase and will present different
aspects of this particular protein. Among them: historical discovery, biological functions …
aspects of this particular protein. Among them: historical discovery, biological functions …
Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome
The recent outbreak of Covid19 has required urgent treatments for numerous patients. No
suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of …
suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of …
[HTML][HTML] O2⋅− and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate
JD Schoenfeld, ZA Sibenaller, KA Mapuskar… - Cancer cell, 2017 - cell.com
Pharmacological ascorbate has been proposed as a potential anti-cancer agent when
combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are …
combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are …
Ascorbic acid: chemistry, biology and the treatment of cancer
J Du, JJ Cullen, GR Buettner - … et Biophysica Acta (BBA)-Reviews on …, 2012 - Elsevier
Since the discovery of vitamin C, the number of its known biological functions is continually
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …
Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy
NS Aboelella, C Brandle, T Kim, ZC Ding, G Zhou - Cancers, 2021 - mdpi.com
Simple Summary Cancer cells are consistently under oxidative stress, as reflected by
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …
High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy
Y Ma, J Chapman, M Levine, K Polireddy… - Science translational …, 2014 - science.org
Ascorbate (vitamin C) was an early, unorthodox therapy for cancer, with an outstanding
safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two …
safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two …
Efficacy of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: a systematic review
Background: Recent investigations on the biochemical pathways after a musculoskeletal
injury have suggested that vitamin C (ascorbic acid) may be a viable supplement to enhance …
injury have suggested that vitamin C (ascorbic acid) may be a viable supplement to enhance …
Ascorbic acid in cancer treatment: let the phoenix fly
Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and …
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and …