High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Two faces of vitamin C—antioxidative and pro-oxidative agent

J Kaźmierczak-Barańska, K Boguszewska… - Nutrients, 2020 - mdpi.com
Vitamin C has been known for decades. It is common in everyday use as an element of the
diet, supplementation, and a preservative. For years, research has been conducted to …

[HTML][HTML] Catalase, a remarkable enzyme: targeting the oldest antioxidant enzyme to find a new cancer treatment approach

C Glorieux, PB Calderon - Biological chemistry, 2017 - degruyter.com
This review is centered on the antioxidant enzyme catalase and will present different
aspects of this particular protein. Among them: historical discovery, biological functions …

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

A Boretti, BK Banik - PharmaNutrition, 2020 - Elsevier
The recent outbreak of Covid19 has required urgent treatments for numerous patients. No
suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of …

[HTML][HTML] O2⋅− and H2O2-mediated disruption of Fe metabolism causes the differential susceptibility of NSCLC and GBM cancer cells to pharmacological ascorbate

JD Schoenfeld, ZA Sibenaller, KA Mapuskar… - Cancer cell, 2017 - cell.com
Pharmacological ascorbate has been proposed as a potential anti-cancer agent when
combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are …

Ascorbic acid: chemistry, biology and the treatment of cancer

J Du, JJ Cullen, GR Buettner - … et Biophysica Acta (BBA)-Reviews on …, 2012 - Elsevier
Since the discovery of vitamin C, the number of its known biological functions is continually
expanding. Both the names ascorbic acid and vitamin C reflect its antiscorbutic properties …

Oxidative stress in the tumor microenvironment and its relevance to cancer immunotherapy

NS Aboelella, C Brandle, T Kim, ZC Ding, G Zhou - Cancers, 2021 - mdpi.com
Simple Summary Cancer cells are consistently under oxidative stress, as reflected by
elevated basal level of reactive oxygen species (ROS), due to increased metabolism driven …

High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy

Y Ma, J Chapman, M Levine, K Polireddy… - Science translational …, 2014 - science.org
Ascorbate (vitamin C) was an early, unorthodox therapy for cancer, with an outstanding
safety profile and anecdotal clinical benefit. Because oral ascorbate was ineffective in two …

Efficacy of vitamin C supplementation on collagen synthesis and oxidative stress after musculoskeletal injuries: a systematic review

NN DePhillipo, ZS Aman, MI Kennedy… - … journal of sports …, 2018 - journals.sagepub.com
Background: Recent investigations on the biochemical pathways after a musculoskeletal
injury have suggested that vitamin C (ascorbic acid) may be a viable supplement to enhance …

Ascorbic acid in cancer treatment: let the phoenix fly

N Shenoy, E Creagan, T Witzig, M Levine - Cancer cell, 2018 - cell.com
Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising
anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and …