Thrombotic microangiopathy (TMA) is a pathological process involving thrombocytopenia,
microangiopathic haemolytic anaemia and microvascular occlusion. TMA is common to …

Pregnancy-associated atypical hemolytic uremic syndrome (aHUS) refers to the thrombotic
microangiopathy resulting from uncontrolled complement activation during pregnancy or the …

Atypical hemolytic uremic syndrome (aHUS) is a rare, genetic, life-threatening disease. The
Global aHUS Registry collects real-world data on the natural history of the disease. Here we …

Haemolytic uraemic syndrome (HUS) is defined by the simultaneous occurrence of
nonimmune haemolytic anaemia, thrombocytopenia and acute renal failure. This leads to …

Cancer-related microangiopathic hemolytic anemia (CR-MAHA) is a paraneoplastic
syndrome characterized by Coombs-negative hemolytic anemia with schistocytes and …

Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy defined by
thrombocytopenia, nonimmune microangiopathic hemolytic anemia, and acute renal failure …

Background Studies of monogenic gastrointestinal diseases have revealed molecular
pathways critical to gut homeostasis and enabled the development of targeted therapies …

The discovery of complement dates to the late 1800s, when Jules Bordet identified an
unknown heat-labile lytic substance in blood that possessed activity against various forms of …

Background. Complement dysregulation occurs in thrombotic microangiopathies (TMAs)
other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients …

A mutual relationship exists between immune activation and mechanisms of thrombus
formation. In particular, elements of the innate immune response such as the complement …