Hair follicle melanocytes initiate autoimmunity in alopecia areata: a trigger point

B Xie, J Sun, X Song - Clinical Reviews in Allergy & Immunology, 2022 - Springer
Alopecia areata (AA) is characterized by common non-scarring alopecia due to autoimmune
disorders. To date, the specific pathogenesis underlying AA remains unknown. Thus, AA …

[HTML][HTML] Autoantigen discovery in the hair loss disorder, alopecia areata: implication of post-translational modifications

SD Jadeja, DJ Tobin - Frontiers in Immunology, 2022 - frontiersin.org
Alopecia areata (AA) is a chronic, multifactorial, polygenic, and heterogeneous disorder
affecting growing hair follicles in susceptible individuals, which results in a non-scarring and …

[HTML][HTML] Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers

E Guttman-Yassky, AB Pavel, A Diaz, N Zhang… - Journal of Allergy and …, 2022 - Elsevier
Background Janus kinase (JAK) inhibitors have shown encouraging results in the treatment
of alopecia areata (AA), an autoimmune form of hair loss, in small, uncontrolled studies and …

Scalp biomarkers during dupilumab treatment support Th2 pathway pathogenicity in alopecia areata

Y Renert‐Yuval, AB Pavel, E Del Duca, P Facheris… - Allergy, 2023 - Wiley Online Library
Background The mechanisms driving alopecia areata (AA) are still unclear, hindering
development of targeted therapeutics. Specific Th2 targeting with dupilumab in AA provides …

Proteomic characterization of atopic dermatitis blood from infancy to adulthood

E Del Duca, Y Renert-Yuval, AB Pavel… - Journal of the American …, 2023 - Elsevier
Background Patients with atopic dermatitis (AD) have systemic biomarker dysregulation that
differs by age group; however, the proteomic characteristics of these age-based changes …

A phase 2a randomized vehicle-controlled multi-center study of the safety and efficacy of delgocitinib in subjects with moderate-to-severe alopecia areata

D Mikhaylov, JW Glickman, E Del Duca, J Nia… - Archives of …, 2023 - Springer
Alopecia areata/AA is an autoimmune cause of nonscarring hair loss. The pathogenesis of
AA involves many immune axes, including Th1/Th2 pathways. Delgocitinib is a pan-Janus …

Alopecia areata: current treatments and new directions

D Dahabreh, S Jung, Y Renert-Yuval, J Bar… - American Journal of …, 2023 - Springer
Alopecia areata is an autoimmune hair loss disease that is non-scarring and is
characterized by chronic inflammation at the hair follicle level. Clinically, patients' …

Alopecia areata: What's new in the epidemiology, comorbidities, and pathogenesis?

T Dainichi, M Iwata, Y Kaku - Journal of Dermatological Science, 2023 - Elsevier
Background Alopecia areata (AA) is a common, acquired, and nonscarring type of hair loss
that affects people of every generation and is intractable in severe and relapsing cases …

Analysis of alopecia areata surveys suggests a threshold for improved patient‐reported outcomes

Y Renert‐Yuval, J Correa da Rosa… - British Journal of …, 2022 - academic.oup.com
Background Although alopecia areata (AA) greatly impacts patients' quality of life (QoL),
there is no adequate validation of AA‐targeted QoL surveys in clinical trials, hindering …

Translational impact of omics studies in alopecia areata: recent advances and future perspectives

FB Basmanav, RC Betz - Expert Review of Clinical Immunology, 2022 - Taylor & Francis
Introduction Alopecia areata (AA) is a non-scarring, hair loss disorder and a common
autoimmune-mediated disease with an estimated lifetime risk of about 2%. To date, the …