Activation of human endogenous retroviruses and its physiological consequences
Human endogenous retroviruses (HERVs) are abundant sequences that persist within the
human genome as remnants of ancient retroviral infections. These sequences became fixed …
human genome as remnants of ancient retroviral infections. These sequences became fixed …
Computational immunogenomic approaches to predict response to cancer immunotherapies
Cancer immunogenomics is an emerging field that bridges genomics and immunology. The
establishment of large-scale genomic collaborative efforts along with the development of …
establishment of large-scale genomic collaborative efforts along with the development of …
Repetitive DNA sequence detection and its role in the human genome
Repetitive DNA sequences playing critical roles in driving evolution, inducing variation, and
regulating gene expression. In this review, we summarized the definition, arrangement, and …
regulating gene expression. In this review, we summarized the definition, arrangement, and …
Guadecitabine plus ipilimumab in unresectable melanoma: five-year follow-up and integrated multi-omic analysis in the phase 1b NIBIT-M4 trial
TMR Noviello, AM Di Giacomo, FP Caruso… - Nature …, 2023 - nature.com
Association with hypomethylating agents is a promising strategy to improve the efficacy of
immune checkpoint inhibitors-based therapy. The NIBIT-M4 was a phase Ib, dose-escalation …
immune checkpoint inhibitors-based therapy. The NIBIT-M4 was a phase Ib, dose-escalation …
LINE-1 retrotransposition and its deregulation in cancers: implications for therapeutic opportunities
C Mendez-Dorantes, KH Burns - Genes & development, 2023 - genesdev.cshlp.org
Abstract Long interspersed element 1 (LINE-1) is the only protein-coding transposon that is
active in humans. LINE-1 propagates in the genome using RNA intermediates via …
active in humans. LINE-1 propagates in the genome using RNA intermediates via …
Splicing neoantigen discovery with SNAF reveals shared targets for cancer immunotherapy
Immunotherapy has emerged as a crucial strategy to combat cancer by “reprogramming” a
patient's own immune system. Although immunotherapy is typically reserved for patients with …
patient's own immune system. Although immunotherapy is typically reserved for patients with …
Towards targeting Transposable elements for cancer therapy
Transposable elements (TEs) represent almost half of the human genome. Historically
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
deemed 'junk DNA', recent technological advancements have stimulated a wave of research …
Using long-read CAGE sequencing to profile cryptic-promoter-derived transcripts and their contribution to the immunopeptidome
Recent studies have shown that the noncoding genome can produce unannotated proteins
as antigens that induce immune response. One major source of this activity is the aberrant …
as antigens that induce immune response. One major source of this activity is the aberrant …
[HTML][HTML] Locus-level L1 DNA methylation profiling reveals the epigenetic and transcriptional interplay between L1s and their integration sites
S Lanciano, C Philippe, A Sarkar, D Pratella… - Cell Genomics, 2024 - cell.com
Summary Long interspersed element 1 (L1) retrotransposons are implicated in human
disease and evolution. Their global activity is repressed by DNA methylation, but …
disease and evolution. Their global activity is repressed by DNA methylation, but …
Prediction of tumor-reactive T cell receptors from scRNA-seq data for personalized T cell therapy
The identification of patient-derived, tumor-reactive T cell receptors (TCRs) as a basis for
personalized transgenic T cell therapies remains a time-and cost-intensive endeavor …
personalized transgenic T cell therapies remains a time-and cost-intensive endeavor …