Many recent reviews of eukaryotic DNA replication have emphasized our current
understanding of either the initiation and regulation of eukaryotic nuclear DNA replication (1 …

Nucleotide excision repair is the major DNA repair mechanism in all species tested. This
repair system is the sole mechanism for removing bulky adducts from DNA, but it repairs …

This text offers an up-to-date review of the field of cancer chemotherapy, including some of
the new approaches to biological treatments of cancer and potential targets for new drug …

Natural tetracyclic diterpenoid aphidicolin is a potent and specific inhibitor of B-family DNA
polymerases, haltering replication and possessing a strong antimitotic activity in human …

Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is an essential DNA repair
enzyme which uses a single active site to process DNA damage via two distinct activities:(1) …

Lag times in DNA synthesis by DNA polymerase delta holoenzyme were due to ATP-
mediated formation of an initiation complex on the primed DNA by the polymerase with the …

Using purified proteins from calf and a synthetic substrate, we have reconstituted the
enzymatic reactions required for mammalian Okazaki fragment processing in vitro. The …

Revised Manuscript Received September 12, 1991 abstract: Current models suggest that
two or more DNA polymerases may be required for high-fidelity semiconservative DNA …

Human flap endonuclease 1 (FEN1), an essential DNA replication protein, cleaves
substrates with unannealed 5′-tails. FEN1 apparently tracks along the flap from the 5 …

The functioning of the eukaryotic genome depends on efficient and accurate DNA replication
and repair. The process of replication is complicated by the ongoing decomposition of DNA …