Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

The transsulfuration pathway is a metabolic pathway where transfer of sulfur from
homocysteine to cysteine occurs. The pathway leads to the generation of several sulfur …

Cysteine, a thiol-containing amino acid, is crucial for the synthesis of sulfur-containing
biomolecules that control multiple essential cellular activities. Altered cysteine metabolism …

Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine
metabolism. Physiologic Hcy levels are determined primarily by dietary intake and vitamin …

The non-essential amino acid cysteine is used within cells for multiple processes that rely on
the chemistry of its thiol group. Under physiological conditions, many non-transformed …

Immune cells survey and patrol throughout the body and sometimes take residence in niche
environments with distinct cellular subtypes and nutrients that may fluctuate from those in …

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Background Ferroptosis is an iron-dependent, lipid peroxide-mediated cell death that may
be exploited to selective elimination of damaged and malignant cells. Recent studies have …

l‐Cysteine is a nutritionally semiessential amino acid and is present mainly in the form of l‐
cystine in the extracellular space. With the help of a transport system, extracellular l‐cystine …

Abstract Significance: Hydrogen sulfide (H2S), produced by the desulfuration of cysteine or
homocysteine, functions as a signaling molecule in an array of physiological processes …