Abstract The von Hippel–Lindau disease is caused by inactivating germline mutations of the
VHL tumour suppressor gene and is associated with an increased risk of a variety of …

Germline inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene causes the
von Hippel-Lindau hereditary cancer syndrome, and somatic mutations of this gene have …

Abstract The von Hippel–Lindau hereditary cancer syndrome was first described about 100
years ago. The unusual clinical features of this disorder predicted a role for the von Hippel …

Inactivation of the von Hippel-Lindau tumor suppressor gene is linked to the development of
hereditary (VHL Disease-associated) and sporadic clear cell carcinoma of the kidney. The …

Biallelic inactivation of the von Hippel–Lindau tumor suppressor gene (VHL) is linked to the
development of hereditary (VHL-associated) and sporadic clear-cell renal carcinomas as …

Abstract von Hippel-Lindau disease, which is characterized by an increased risk of
hemangioblastomas, clear cell renal carcinomas, and pheochromocytomas, is caused by …

Germ line VHL tumor suppressor gene loss-of-function mutations cause von Hippel-Lindau
disease, which is associated with an increased risk of central nervous system …

Abstract Mutations in von Hippel-Lindau tumor suppressor gene (VHL) underlie the VHL
hereditary cancer syndrome and also occur in most sporadic clear cell renal cell cancers …

The product of the von Hippel-Lindau gene (VHL) acts as the substrate-recognition
component of an E3 ubiquitin ligase complex that ubiquitylates the catalytic α subunit of …

Renal cell carcinoma (RCC) is the most lethal of the common urologic malignancies, with
approximately 40% of patients eventually dying of cancer progression. Approximately one …