The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

Major depressive disorder is a debilitating disorder affecting millions of people each year.
Brain-derived neurotrophic factor (BDNF) and inflammation are two prominent biologic risk …

Neurodegenerative diseases (NDDs) are leading causes of death and morbidity in the
elderly worldwide. From the mechanistic/pathological view, oxidative stress, inflammation …

An accumulating body of evidence suggests that the bacterium Akkermansia muciniphila
exhibits positive systemic effects on host health, mainly by improving immunological and …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in
the brain, and is one of the most widely investigated molecule in psychiatric disorders. The …

The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes
neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the …

A significant proportion of the global burden of disease can be attributed to mental illness.
Despite important advances in identifying risk factors for mental health conditions, the …

Indole acetic acid (IAA), an intestinal bacteria-derived tryptophan metabolite, has been
detected at abnormal concentrations in the cerebrospinal fluid and urine of depressed …