AAA revisited: a comprehensive review of risk factors, management, and hallmarks of pathogenesis

V Kessler, J Klopf, W Eilenberg, C Neumayer… - Biomedicines, 2022 - mdpi.com
Despite declining incidence and mortality rates in many countries, the abdominal aortic
aneurysm (AAA) continues to represent a life-threatening cardiovascular condition with an …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

[HTML][HTML] Editor's Choice--European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Abdominal Aorto-Iliac Artery …

A Wanhainen, I Van Herzeele, FB Goncalves… - European Journal of …, 2024 - Elsevier
Abstract Objective The European Society for Vascular Surgery (ESVS) has developed
clinical practice guidelines for the care of patients with aneurysms of the abdominal aorta …

Twenty years of studying AngII (angiotensin II)-induced abdominal aortic pathologies in mice: continuing questions and challenges to provide insight into the human …

H Sawada, HS Lu, LA Cassis… - … thrombosis, and vascular …, 2022 - Am Heart Assoc
AngII (angiotensin II) infusion in mice has been used to provide mechanistic insight into
human abdominal aortic aneurysms for over 2 decades. This is a technically facile animal …

Mouse models for abdominal aortic aneurysm

J Golledge, SM Krishna, Y Wang - British Journal of …, 2022 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year.
Currently, the only treatment for AAA is surgical repair; however, this is only indicated for …

Development of pharmacotherapies for abdominal aortic aneurysms

LM Weaver, CD Loftin, CG Zhan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …

Novel pharmacological approaches in abdominal aortic aneurysm

L Puertas-Umbert, R Almendra-Pegueros… - Clinical …, 2023 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

[HTML][HTML] Angiotensin-converting enzyme 2, coronavirus disease 2019, and abdominal aortic aneurysms

B Xu, G Li, J Guo, T Ikezoe, K Kasirajan, S Zhao… - Journal of Vascular …, 2021 - Elsevier
Objective Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the etiologic
agent of the current, world-wide coronavirus disease 2019 (COVID-19) pandemic …

[HTML][HTML] Role of smooth muscle YAP and TAZ in protection against phenotypic modulation, inflammation, and aneurysm development

F Daoud, MA Martínez, J Holst, J Holmberg… - Biochemical …, 2022 - Elsevier
A ruptured arterial aneurysm, especially in the aorta, represents one of the most acute and
mortal conditions encountered in clinical medicine. Population-based screening in elderly …

Pharmacotherapy in clinical trials for abdominal aortic aneurysms: A systematic review and meta-analysis

Z Su, J Guo, Y Gu - Clinical and Applied Thrombosis …, 2022 - journals.sagepub.com
Objective There is no medical treatment proven to limit abdominal aortic aneurysm (AAA)
progression. This systematic review aimed to summarise available trial evidence on the …