Hepatocarcinogenesis is a slow process during which genomic changes progressively alter
the hepatocellular phenotype to produce cellular intermediates that evolve into …

The existence of genetic alterations affecting genes involved in cellular proliferation and
death, such as TP53 and K-ras, is one of the most common features of tumour cells …

We are in an era where the potential exists for deriving comprehensive profiles of DNA
alterations characterizing each form of human cancer. Such profiles would provide …

Hepatocellular carcinoma (HCC) is one of the most fatal human malignancies, but the
molecular mechanisms of hepatocarcinogenesis remain unclear. Although p53 mutations …

Esophageal adenocarcinoma (EAC) arises after normal squamous mucosa undergoes
metaplasia to specialized columnar epithelium (intestinal metaplasia or Barrett's …

To determine the methylation profile of multiple tumor-related genes during multistep
hepatocarcinogenesis, we investigated the methylation status of CpG islands of 9 genes …

Promoter hypermethylation of the glutathione S-transferase P1 gene (GSTP1) is the most
frequent DNA alteration in prostatic carcinoma. Because this epigenetic DNA alteration can …

Compiling significant advances from more than a decade of research, this text presents
breakthroughs in the prevention, treatment, and control of cancer-exploring the origin …

GSTP1 CpG island hypermethylation is the most common somatic genome alteration
described for human prostate cancer (PCA); lack of GSTP1 expression is characteristic of …

Prostate cancer is an increasing threat throughout the world. As a result of a demographic
shift in population, the number of men at risk for developing prostate cancer is growing …