Histone post-translational modifications—cause and consequence of genome function
G Millán-Zambrano, A Burton, AJ Bannister… - Nature Reviews …, 2022 - nature.com
Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
(PTMs) and how they affect DNA-templated processes at the molecular level. This …
[HTML][HTML] Chronic inflammation and the hallmarks of aging
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
Lateral thinking: how histone modifications regulate gene expression
M Lawrence, S Daujat, R Schneider - Trends in Genetics, 2016 - cell.com
The DNA of each cell is wrapped around histone octamers, forming so-called 'nucleosomal
core particles'. These histone proteins have tails that project from the nucleosome and many …
core particles'. These histone proteins have tails that project from the nucleosome and many …
Born to run: control of transcription elongation by RNA polymerase II
FX Chen, ER Smith, A Shilatifard - Nature reviews Molecular cell …, 2018 - nature.com
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
Histone core modifications regulating nucleosome structure and dynamics
P Tessarz, T Kouzarides - Nature reviews Molecular cell biology, 2014 - nature.com
Post-translational modifications of histones regulate all DNA-templated processes, including
replication, transcription and repair. These modifications function as platforms for the …
replication, transcription and repair. These modifications function as platforms for the …
[HTML][HTML] Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive
complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene …
complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene …
Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes
Histone lysine methylations have primarily been linked to selective recruitment of reader or
effector proteins that subsequently modify chromatin regions and mediate genome functions …
effector proteins that subsequently modify chromatin regions and mediate genome functions …
High-resolution profiling of histone methylations in the human genome
Histone modifications are implicated in influencing gene expression. We have generated
high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine …
high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine …
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
We report the application of single-molecule-based sequencing technology for high-
throughput profiling of histone modifications in mammalian cells. By obtaining over four …
throughput profiling of histone modifications in mammalian cells. By obtaining over four …
Structure and function of mammalian DNA methyltransferases
DNA methylation plays an important role in epigenetic signalling, having an impact on gene
regulation, chromatin structure, development and disease. Here, we review the structures …
regulation, chromatin structure, development and disease. Here, we review the structures …