The risk for major depression is both genetically and environmentally determined. It has
been proposed that epigenetic mechanisms could mediate the lasting increases in …

DNA methylation (DNAm)–an epigenetic process that regulates gene expression–may
represent a mechanism for the biological embedding of early traumatic experiences …

A number of prenatal experiences are associated with adverse outcomes after birth, ranging
from cardiovascular problems to psychiatric disease. Prenatal stress is associated with …

There is substantial variation in people's responses to adversity, with a considerable
proportion of individuals displaying psychological resilience. Epigenetic mechanisms are …

Stress is defined as a state of threatened or perceived as threatened homeostasis. The well-
tuned coordination of the stress response system is necessary for an organism to respond to …

Identification and characterisation of novel targets for treatment is a priority in the field of
psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a …

Chronic environmental stress can profoundly impact cell and body function. Although the
underlying mechanisms are poorly understood, epigenetics has emerged as a key link …

Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime
prevalence of 20% and, thus, is one of the most prevalent mental health disorders …

Childhood trauma (CT) is well established as a potent risk factor for the development of
mental disorders. However, the potential of adverse early experiences to exert chronic and …

Humanized mouse models can be used to explore human gene regulatory elements (REs),
which frequently lie in non-coding and less conserved genomic regions. Epigenetic …