Oocyte aging: cellular and molecular changes, developmental potential and reversal possibility
YL Miao, K Kikuchi, QY Sun… - Human reproduction …, 2009 - academic.oup.com
BACKGROUND In humans, normal healthy children are regularly produced through
fertilization of fresh oocytes with fresh spermatozoa. However, asynchrony between oocytes …
fertilization of fresh oocytes with fresh spermatozoa. However, asynchrony between oocytes …
[HTML][HTML] Complex networks of multiple factors in the pathogenesis of uterine leiomyoma
OBJECTIVE: To summarize the information regarding pathogenetic factors of leiomyoma
formation and growth, and to make a simple integrated pathogenetic view of this tumor for …
formation and growth, and to make a simple integrated pathogenetic view of this tumor for …
Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
V Valinluck, HH Tsai, DK Rogstad, A Burdzy… - Nucleic acids …, 2004 - academic.oup.com
Cytosine methylation in CpG dinucleotides is believed to be important in gene regulation,
and is generally associated with reduced levels of transcription. Methylation-mediated gene …
and is generally associated with reduced levels of transcription. Methylation-mediated gene …
A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases
Dicer initiates RNA interference by generating small RNAs involved in various silencing
pathways. Dicer participates in centromeric silencing, but its role in the epigenetic regulation …
pathways. Dicer participates in centromeric silencing, but its role in the epigenetic regulation …
[HTML][HTML] Methyl-CpG-binding protein, MeCP2, is a target molecule for maintenance DNA methyltransferase, Dnmt1
H Kimura, K Shiota - Journal of Biological Chemistry, 2003 - ASBMB
During mammalian cell division, DNA methylation patterns are transferred accurately to the
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …
newly synthesized DNA strand. This depends on maintenance DNA methyltransferase …
Molecular signatures of pancreatic cancer
Context.—The introduction of genome-and epigenome-wide screening techniques has
dramatically improved our understanding of the molecular mechanisms underlying the …
dramatically improved our understanding of the molecular mechanisms underlying the …
DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen
Y Yamagata, H Asada, I Tamura, L Lee… - Human …, 2009 - academic.oup.com
BACKGROUND Epigenetic regulation may be involved in modulation of gene expression
during the normal cyclic changes of the human endometrium. We investigated expression of …
during the normal cyclic changes of the human endometrium. We investigated expression of …
Non-coding RNA directed DNA demethylation of Sphk1 CpG island
The formation of DNA methylation patterns is one of the epigenetic events that underlie
mammalian development. The Sphk1 CpG island is a target for tissue-dependent DNA …
mammalian development. The Sphk1 CpG island is a target for tissue-dependent DNA …
[HTML][HTML] DNA methylation-mediated control of Sry gene expression in mouse gonadal development
DNA methylation at CpG sequences is involved in tissue-specific and developmentally
regulated gene expression. The Sry (sex-determining region on the Y chromosome) gene …
regulated gene expression. The Sry (sex-determining region on the Y chromosome) gene …
[HTML][HTML] Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas
R Maekawa, S Sato, Y Yamagata, H Asada, I Tamura… - PloS one, 2013 - journals.plos.org
Background The pathogenesis of uterine leiomyomas, the most common benign tumor in
women, remains unclear. Since acquired factors such as obesity, hypertension and early …
women, remains unclear. Since acquired factors such as obesity, hypertension and early …