Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …

Epigenetics refers to a variety of processes that have heritable effects on gene expression
programs without changes in DNA sequence. Key players in epigenetic control are chemical …

Rett syndrome (RTT) is a severe and progressive neurological disorder, which mainly affects
young females. Mutations of the methyl-CpG binding protein 2 (MECP2) gene are the most …

Curcumin (CUR), a major bioactive polyphenolic component from turmeric curry, Curcuma
longa, has been shown to be a potent anti-cancer phytochemical with well-established anti …

Within the central nervous system, microRNAs have emerged as important effectors of an
array of developmental, physiological, and cognitive processes. Along these lines, the …

Proteins are dynamic creatures. Intrinsically disordered proteins (IDPs) function as
multiplicity of structures and their activities can only be described by stochastic structure …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …

Traditionally, specific DNA recognition is thought to rely on static contacts with the bases or
phosphates. Recent results, however, indicate that residues far outside the binding context …

Background Chronic methamphetamine (METH) exposure causes neuroadaptations at
glutamatergic synapses. Methods To identify the METH-induced epigenetic underpinnings …

Since the discovery of its fundamental involvement in Rett syndrome, methyl CpG binding
protein 2 (MeCP2) has been the focus of an exhaustive biochemical and functional …