Endogenous retroviruses as modulators of innate immunity
E Russ, S Iordanskiy - Pathogens, 2023 - mdpi.com
Endogenous retroviruses (ERVs), or LTR retrotransposons, are a class of transposable
elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make …
elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make …
Intrinsic signalling factors associated with cancer cell-cell fusion
T Dittmar, R Hass - Cell Communication and Signaling, 2023 - Springer
Cellular fusion eg between cancer cells and normal cells represents a stepwise process that
is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer …
is tightly regulated. During a pre-hybrid preparation program somatic cells and/or cancer …
Human endogenous retroviruses: our genomic fossils and companions
RA Stein, RV DePaola - Physiological Genomics, 2023 - journals.physiology.org
Approximately 8% of the human genome, over four times more than its protein-coding
regions, comprises sequences of viral origin that are known as human endogenous …
regions, comprises sequences of viral origin that are known as human endogenous …
Extracellular events involved in cancer cell–cell fusion
T Dittmar, R Hass - International Journal of Molecular Sciences, 2022 - mdpi.com
Fusion among different cell populations represents a rare process that is mediated by both
intrinsic and extracellular events. Cellular hybrid formation is relayed by orchestrating tightly …
intrinsic and extracellular events. Cellular hybrid formation is relayed by orchestrating tightly …
Envelope Recombination: A Major Driver in Shaping Retroviral Diversification and Evolution within the Host Genome
Endogenous retroviruses (ERVs) are integrated into host DNA as the result of ancient germ
line infections, primarily by extinct exogenous retroviruses. Thus, vertebrates' genomes …
line infections, primarily by extinct exogenous retroviruses. Thus, vertebrates' genomes …
The important biological roles of Syncytin-1 of human endogenous retrovirus W (HERV-W) and Syncytin-2 of HERV-FRD in the human placenta development
M Gholami Barzoki, S Shatizadeh Malekshahi… - Molecular Biology …, 2023 - Springer
Abstract Background: Human endogenous retroviruses (HERVs) entered the germ line by
retroviral infection from a distant ancestor over 30 million years ago and constitute 8% of the …
retroviral infection from a distant ancestor over 30 million years ago and constitute 8% of the …
A comprehensive investigation of human endogenous retroviral syncytin proteins and their receptors in men with normozoospermia and impaired semen quality
Purpose The study aims to investigate first the presence of Syncytin 2 and its receptor,
MFSD2, in human sperm, and second whether the expressions of Syncytin 1, Syncytin 2 …
MFSD2, in human sperm, and second whether the expressions of Syncytin 1, Syncytin 2 …
Molecular mechanisms of syncytin-1 in tumors and placental development related diseases
Q Wang, Y Shi, Q Bian, N Zhang, M Wang, J Wang… - Discover Oncology, 2023 - Springer
Human endogenous retroviruses (HERVs) have evolved from exogenous retroviruses and
account for approximately 8% of the human genome. A growing number of findings suggest …
account for approximately 8% of the human genome. A growing number of findings suggest …
Immune suppression of vaccine-induced CD8+ T-cell responses by gamma retrovirus envelope is mediated by interleukin-10-producing CD4+ T cells
P Podschwadt, A Malyshkina, S Windmann… - Frontiers in …, 2022 - frontiersin.org
Retroviral envelope (Env) proteins have long been recognized to exhibit
immunosuppressive properties, which affect the CD8+ T-cell response to an infection but …
immunosuppressive properties, which affect the CD8+ T-cell response to an infection but …
Why do certain cancer cells alter functionality and fuse?
T Dittmar, M Sieler, R Hass - Biological Chemistry, 2023 - degruyter.com
Cancer cell fusion represents a rare event. However, the surviving cancer hybrid cells after a
post-hybrid selection process (PHSP) can overgrow other cancer cells by exhibiting a …
post-hybrid selection process (PHSP) can overgrow other cancer cells by exhibiting a …