DNA methyltransferases are an essential class of modifiers in epigenetics. In mammals,
DNMT1, DNMT3A and DNMT3B participate in DNA methylation to regulate normal …

DNA methylation is an epigenetic mark that regulates multiple processes, such as gene
expression and genome stability. Mutants and pharmacological treatments have been …

Background Cytosine DNA methylation is widely described as a transcriptional repressive
mark with the capacity to silence promoters. Epigenome engineering techniques enable …

Abstract Intracellular adhesion molecule 1 (ICAM-1) is one of the most extensively studied
inducible cell adhesion molecules which is responsible for several immune functions like T …

Epigenetic editing refers to the locus-specific targeting of epigenetic enzymes to rewrite the
local epigenetic landscape of an endogenous genomic site, often with the aim of …

Epigenetic alterations, such as promoter hypermethylation, may drive cancer through tumor
suppressor gene inactivation. However, we have limited ability to differentiate driver DNA …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Most studies in the field of ecology and evolution aiming to connect genotype to phenotype
rarely validate identified loci using functional tools. Recent developments in RNA …

Eukaryotic DNA methylation prevents genomic instability by regulating the expression of
oncogenes and tumor-suppressor genes. The negative effects of dysregulated DNA …

Epigenome editing is a promising technology, potentially allowing the stable reprogramming
of gene expression profiles without alteration of the DNA sequence. Targeted DNA …