Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …

The four-dimensional nucleome (4DN) consortium studies the architecture of the genome
and the nucleus in space and time. We summarize progress by the consortium and highlight …

Chromosome conformation capture (3C) technologies reveal the incredible complexity of
genome organization. Maps of increasing size, depth, and resolution are now used to probe …

Transcription reprogramming during cell differentiation involves targeting enhancers to
genes responsible for establishment of cell fates. To understand the contribution of CTCF …

Abstract Three-dimensional (3D) epigenome remodeling is an important mechanism of gene
deregulation in cancer. However, its potential as a target to counteract therapy resistance …

Contacts between enhancers and promoters are thought to relate to their ability to activate
transcription. Investigating factors that contribute to such chromatin interactions is therefore …

Precise spatiotemporal regulation of gene expression is of paramount importance for
eukaryotic development. The maternal-to-zygotic transition (MZT) during early …

Cellular senescence, a persistent form of cell cycle arrest, has been linked to the formation
of heterochromatic foci, accompanied by additional concentric epigenetic layers. However …

In eukaryotic cells, genome duplication is temporally organised according to a program
referred to as the replication-timing (RT) program. The RT of individual genomic domains …

Decades of work on the spatiotemporal organization of mammalian DNA replication timing
(RT) continues to unveil novel correlations with aspects of transcription and chromatin …