Carcinogenesis is accompanied by widespread DNA methylation changes within the cell.
These changes are characterized by a globally hypomethylated genome with focal …

DNA methylation is an important epigenetic modification of DNA in mammalian genomes.
DNA methylation patterns are established early in development, modulated during tissue …

During the polymerase chain reaction (PCR), which is a versatile and widely used method,
certain DNA sequences are rapidly amplified through thermocycling. Although there are …

Background Nonmelanoma skin cancer is caused by exposure to ultraviolet radiation within
sunlight. Actinic keratoses (AKs) are benign precursor lesions that can develop into invasive …

We have developed a novel technique for specific amplification of rare methylated DNA
fragments in a high background of unmethylated sequences that avoids the need of …

During the past few decades, it has become increasingly apparent that heredity is not the
sole determining factor in disease development, such as cancer. This landmark work covers …

Genomic DNA methylation is one of three epigenomic mechanisms controlling DNA
expression. It is involved in various aspects of development and other biological …

Over the past ten years, interest in epigenetic has rapidly increased. Heritable and stable
changes in gene expression without any change in DNA sequence is in the field of …

The present invention relates generally to nucleic acid molecules in respect of which
changes to DNA methylation levels are indicative of the onset or predisposition to the onset …