Astrocyte involvement in blood–brain barrier function: a critical update highlighting novel, complex, neurovascular interactions

DR Manu, M Slevin, L Barcutean, T Forro… - International Journal of …, 2023 - mdpi.com
Neurological disorders have been linked to a defective blood–brain barrier (BBB), with
dysfunctions triggered by stage-specific disease mechanisms, some of these being …

[HTML][HTML] Role of primary aging hallmarks in Alzheimer´ s disease

J Zhao, J Huai - Theranostics, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Comparative analysis between 2D and 3D colorectal cancer culture models for insights into cellular morphological and transcriptomic variations

ZN Abbas, AZ Al-Saffar, SM Jasim, GM Sulaiman - Scientific Reports, 2023 - nature.com
Drug development is a time-consuming and expensive process, given the low success rate
of clinical trials. Now, anticancer drug developments have shifted to three-dimensional (3D) …

Mesenchymal cells in the Lung: Evolving concepts and their role in fibrosis

G Ligresti, AA Raslan, J Hong, N Caporarello… - Gene, 2023 - Elsevier
Mesenchymal cells in the lung are crucial during development, but also contribute to the
pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most …

[HTML][HTML] Epigenetic control of inflammation in Atopic Dermatitis

S Akhtar, RKME Alsayed, F Ahmad… - Seminars in Cell & …, 2024 - Elsevier
Atopic dermatitis (AD), also known as atopic eczema, is a common but also complex chronic,
itchy skin condition with underlying inflammation of the skin. This skin ailment is prevalent …

[HTML][HTML] Comparative hepatotoxicity of novel lithium bis (trifluoromethanesulfonyl) imide (LiTFSI, ie. HQ-115) and legacy Perfluorooctanoic acid (PFOA) in male mice …

M Sands, X Zhang, M Laws, M Spinella… - Environment …, 2024 - Elsevier
Abstract Lithium Bis (trifluoromethanesulfonyl) imide (LiTFSI ie. HQ-115), a polymer
electrolyte used in energy applications, has been detected in the environment, yet its health …

Mechanisms of human DNA methylation, alteration of methylation patterns in physiological processes and oncology

A Sergeeva, K Davydova, A Perenkov, M Vedunova - Gene, 2023 - Elsevier
DNA methylation is one of the epigenetic modifications of the genome, the essence of which
is the attachment of a methyl group to nitrogenous bases. In the eukaryote genome, cytosine …

[HTML][HTML] Methylome-wide analysis of milk somatic cells upon subclinical mastitis in dairy cattle

D Giannuzzi, E Capra, V Bisutti, A Vanzin… - Journal of Dairy …, 2024 - Elsevier
Better understanding of the molecular mechanisms behind bovine mastitis is fundamental
for improving the management of this disease, which continues to be of major concern for …

[HTML][HTML] Targeted DNA methylation analysis and prediction of smoking habits in blood based on massively parallel sequencing

A Vidaki, BP Jiménez, B Poggiali, V Kalamara… - Forensic Science …, 2023 - Elsevier
Tobacco smoking is a frequent habit sustained by> 1.3 billion people in 2020 and the
leading preventable factor for health risk and premature mortality worldwide. In the forensic …

[HTML][HTML] Maternal SARS-CoV-2 exposure alters infant DNA methylation

RA Hill, A Gibbons, U Han, W Suwakulsiri… - Brain, Behavior, & …, 2023 - Elsevier
Background Infection during pregnancy can increase the risk of neurodevelopmental
disorders in offspring. The impact of maternal SARS-CoV-2 infection on infant …