Polycystic kidney disease (PKD), a common genetic cause of chronic renal failure in
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …

Sullivan, Lawrence P., Darren P. Wallace, and Jared J. Grantham. Epithelial Transport in
Polycystic Kidney Disease. Physiol. Rev. 78: 1165–1191, 1998.—In autosomal dominant …

Germline mutations in PKD2 cause autosomal dominant polycystic kidney disease. We have
introduced a mutant exon 1 in tandem with the wild-type exon 1 at the mouse Pkd2 locus …

PKD1 is the most common site for mutations in human autosomal dominant polycystic
kidney disease (ADPKD). ADPKD is characterized by progressive replacement of kidney …

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by cyst formation
in the kidney, liver, and pancreas and is associated often with cardiovascular abnormalities …

Autosomal dominant polycystic kidney disease (ADPKD), often caused by mutations in the
PKD1 gene, is associated with life-threatening vascular abnormalities that are commonly …

Two distinct signaling pathways, involving Wnt signaling and polycystin, have been found to
be critical for normal kidney development. Renal tubulogenesis requires the presence of …

A second gene for autosomal dominant polycystic kidney disease (ADPKD), PKD2, has
been recently identified. Using antisera raised to the human PKD2 protein, polycystin-2, we …

Autosomal-dominant polycystic kidney disease, one of the most frequent human genetic
disorders, is genetically heterogeneous. Most cases result from mutations of PKD1 or PKD2 …

The excretory cell extends a tubular process, or canal, along the basolateral surface of the
epidermis to form the nematode renal epithelium. This cell can undergo normal …