Background Age‐related differences in the pharmacokinetics and pharmacodynamics of
neuromuscular blocking agents (NMBAs) and the short duration of many surgical …

The use of pharmacokinetic-pharmacodynamic models has improved anaesthesia practice
in children through a better understanding of dose-concentration-response relationships …

Pharmacokinetic‐pharmacodynamic modeling and simulation can facilitate understanding
and prediction of exposure‐response relationships in children with acute or chronic pain …

Plasma drug concentration is the variable linking dose to effect. The decrement time
required for plasma concentration of anesthetic agents to decrease by 50%(context …

Pharmacokinetic pharmacodynamic modeling is an important tool which uses statistical
methodology to provide a better understanding of the relationship between concentration …

The conventional ways employed in the preformulation, formulation, and in vivo studies are
based on trial-and-error experiments, which are time consuming, expensive, and with limited …

Pharmacokinetic pharmacodynamic models are used in adult and paediatric anaesthesia.
The pharmacokinetic parameter volume is used to calculate loading dose while …

The wellbeing highlights of sedative machines and the accessibility of precise gas observing
today beat the greater part of the specialized deficiencies and balance previous protection …