Background Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in
the Fibrillin-1 gene (FBN1). Here, we undertook the first epigenome-wide association study …

The type and pattern of epigenetic modification in donor cells can significantly affect the
developmental competency of somatic cell nuclear transfer (SCNT) embryos. Here, we …

Background/Aims: DNA methylation and histone modifications are essential epigenetic
marks that can significantly affect the mammalian somatic cell nuclear transfer (SCNT) …

Epigenetic mechanisms play an important role in oogenesis and early embryo development
in mammals. Dimethyl sulfoxide (DMSO) is frequently used as a solvent in biological studies …

RUNX2 is a transcription factor crucial for bone formation. Mutant mice with varying levels of
Runx2 expression display dosage-dependent skeletal abnormalities, underscoring the …

Abstract Fibrillin-1 (FBN1) is responsible for haploinsufficient and autosomal dominant
Marfan syndrome. Even in the same Marfan pedigree, penetrance and expressivity in …

Background Marfan syndrome (MFS) is a rare genetic disorder caused by mutations in the
Fibrillin‐1 gene (FBN1) with significant clinical features in the skeletal, cardiopulmonary, and …

Testicular aromatase catalyzes the synthesis of estradiol, which contributes to regulation of
porcine Sertoli cell proliferation and postpubertal maintenance of Sertoli cell numbers …