Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …

The aorta is the largest artery in the body, delivering oxygenated blood from the left ventricle
to all organs. Dissection of the aorta is a lethal condition caused by a tear in the intimal layer …

The improvements in healthcare services and quality of life result in a longer life expectancy
and a higher number of aged individuals, who are inevitably affected by age-associated …

Metabolic reprogramming of vascular smooth muscle cell (VSMC) plays a critical role in the
pathogenesis of thoracic aortic dissection (TAD). Previous researches have mainly focused …

In recent years, a new target closely linked to a variety of diseases has appeared in the
researchers' vision, which is the NLRP3 inflammasome. With the deepening of the study of …

Large-vessel vasculitis (LVV) are autoimmune and autoinflammatory diseases focused on
vascular inflammation. The central core of the intricate immunological and molecular …

Tryptophan, an essential dietary amino acid, is metabolized into various metabolites within
both gut microbiota and tissue cells. These metabolites have demonstrated potential …

Background Pulmonary hypertension (PH) is characterized by progressive pulmonary
arterial remodelling, associated with different severities of inflammation and altered immune …

Background A novel hematologic parameter, systemic coagulation-inflammation (SCI) index
reflecting inflammation and coagulation pathways could be easily obtained from clinically …

Cardiovascular disease remains the leading cause of death worldwide, characterized by
atherosclerotic activity within large and medium‐sized arteries. Inflammation has been …