It is well-recognized that, despite similar pain characteristics, some people with chronic pain
recover, whereas others do not. In this review, we discuss possible contributions and …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

The fact that not all individuals exposed to the same environmental risk factors develop
obesity supports the hypothesis of the existence of underlying genetic and epigenetic …

Primary Sjögren's syndrome (pSS) is a complex disabling systemic autoimmune disorder.
The hallmark of pSS is the T-cell-mediated hyperactivation of B-cells, evolving from …

Epigenetics is one of the most rapidly expanding fields in biology. The recent
characterization of a human DNA methylome at single nucleotide resolution, the discovery of …

More than 20 years ago, Wood et al.(Curr Anthropol 33: 343–370, 1992) published “The
Osteological Paradox: Problems of Inferring Prehistoric Health from Skeletal Samples,” in …

ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

DNA N4-methylcytosine (4mC) is an important genetic modification and plays crucial roles in
differentiation between self and non-self DNA and in controlling DNA replication, cell cycle …

DNA methylation by de novo DNA methyltransferases 3A (DNMT3A) and 3B (DNMT3B) at
cytosines is essential for genome regulation and development,. Dysregulation of this …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …