A majority of human papillomavirus (HPV) infections are asymptomatic and self-resolving in
the absence of medical interventions. Various innate and adaptive immune responses, as …

Importance Recent large-scale genome-wide association studies have discovered several
genetic variants associated with Alzheimer disease (AD); however, the extent to which DNA …

Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

Betaine is an essential osmolyte and source of methyl groups and comes from either the diet
or by the oxidation of choline. Its metabolism methylates homocysteine to methionine, also …

Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two
counteracting enzyme families whose enzymatic activity controls the acetylation state of …

Nutrition plays an important role in the prevention and management of disease. Whole grain
cereals contain a host of nutrients and bioactive substances that have health-promoting …

Mammary stem/progenitor cells (MaSCs) maintain self-renewal of the mammary epithelium
during puberty and pregnancy. DNA methylation provides a potential epigenetic mechanism …

DNA methylation has been linked to aberrant silencing of tumor suppressor genes in cancer,
and an imbalance in DNA methylation–demethylation cycles is intimately implicated in the …

DNA methyltransferases (DNMTs) establish and maintain DNA methylation patterns at
specific regions of the genome, thereby contributing to gene regulation. It is becoming …

Cytosine methylation is a repressive, epigenetically propagated DNA modification. Although
patterns of DNA methylation seem tightly regulated in mammals, it is unclear how these are …