Central nervous system (CNS) development, homeostasis, stress responses, and plasticity
are all mediated by epigenetic mechanisms that modulate gene expression and promote …

Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

DNA methylation is an epigenetic modification that plays an important role in gene
expression regulation, development, and disease. Recent technological innovations have …

Post-translational modifications (PTMs) occur in almost all proteins and play an important
role in numerous biological processes by significantly affecting proteins' structure and …

Articular chondrocytes are quiescent, fully differentiated cells responsible for the
homeostasis of adult articular cartilage by maintaining cellular survival functions and the fine …

Abstract TET enzymes oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC),
which can lead to DNA demethylation. However, direct connections between TET-mediated …

DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b cooperatively regulate cytosine
methylation in CpG dinucleotides in mammalian genomes, providing an epigenetic basis for …

Many enzymes are inhibited by their own substrates, leading to velocity curves that rise to a
maximum and then descend as the substrate concentration increases. Substrate inhibition is …

The ability of an environmental exposure to induce an epigenetic transgenerational adult
onset disease phenotype is discussed in the current mini-review in the context of defining …

Abstract Angiotensin-converting enzyme 2 (ACE2) is a member of the renin-angiotension
system, however, the correlation between ACE2 and prognosis in UCEC (Uterine Corpus …