[HTML][HTML] Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: the role of Epstein–Barr virus and the gut–brain axis

K Hashimoto - Molecular Psychiatry, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public …

[HTML][HTML] Emerging role of the host microbiome in neuropsychiatric disorders: overview and future directions

K Hashimoto - Molecular Psychiatry, 2023 - nature.com
The human body harbors a diverse ecosystem of microorganisms, including bacteria,
viruses, and fungi, collectively known as the microbiota. Current research is increasingly …

[HTML][HTML] Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation

X Wang, Z Wang, J Cao, Y Dong, Y Chen - Microbiome, 2023 - Springer
Background Sleep loss is a serious global health concern. Consequences include memory
deficits and gastrointestinal dysfunction. Our previous research showed that melatonin can …

[HTML][HTML] Arketamine, a new rapid-acting antidepressant: a historical review and future directions

J Zhang, W Yao, K Hashimoto - Neuropharmacology, 2022 - Elsevier
The N-methyl-d-aspartate receptor (NMDAR) antagonist (R, S)-ketamine causes rapid onset
and sustained antidepressant actions in treatment-resistant patients with major depressive …

Fish disease and intestinal microbiota: A close and indivisible relationship

D Medina‐Félix, E Garibay‐Valdez… - Reviews in …, 2023 - Wiley Online Library
The gut microbiota is currently one of the most studied 'organs' in animals, and fish are no
exception. A complex diversity of microbes, including bacteria, archaea, yeast and fungus …

[HTML][HTML] Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

C Tan, Q Yan, Y Ma, J Fang, Y Yang - Frontiers in Neurology, 2022 - frontiersin.org
Depression is a worldwide disease causing severe disability, morbidity, and mortality.
Despite abundant studies, the precise mechanisms underlying the pathophysiology of …

A role of gut–microbiota–brain axis via subdiaphragmatic vagus nerve in depression-like phenotypes in Chrna7 knock-out mice

Y Yang, A Eguchi, X Wan, L Chang, X Wang… - Progress in Neuro …, 2023 - Elsevier
The α7 subtype of the nicotinic acetylcholine receptor (α7 nAChR: coded by Chrna7) is
known to regulate the cholinergic ascending anti-inflammatory pathway. We previously …

[HTML][HTML] Arketamine for cognitive impairment in psychiatric disorders

K Hashimoto - European Archives of Psychiatry and Clinical …, 2023 - Springer
Cognitive impairment has been observed in patients with various psychiatric disorders,
including schizophrenia, major depressive disorder (MDD), and bipolar disorder (BD) …

The microbiota–gut–brain axis and neurodevelopmental disorders

Q Wang, Q Yang, X Liu - Protein & Cell, 2023 - academic.oup.com
The gut microbiota has been found to interact with the brain through the microbiota–gut–
brain axis, regulating various physiological processes. In recent years, the impacts of the gut …

[HTML][HTML] Key role of the gut–microbiota–brain axis via the subdiaphragmatic vagus nerve in demyelination of the cuprizone-treated mouse brain

X Wang, A Eguchi, Y Yang, L Chang, X Wan… - Neurobiology of …, 2023 - Elsevier
Multiple sclerosis (MS) is the most common demyelinating disease that attacks the central
nervous system. Dietary intake of cuprizone (CPZ) produces demyelination resembling that …