[HTML][HTML] The placental epigenome as a molecular link between prenatal exposures and fetal health outcomes through the DOHaD hypothesis

S Lapehn, AG Paquette - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review The developmental origins of health and disease (DOHaD)
hypothesis posits that the perinatal environment can impact fetal and later life health. The …

[HTML][HTML] In-utero exposure to air pollution and early-life neural development and cognition

C Yi, Q Wang, Y Qu, J Niu, BG Oliver, H Chen - … and environmental safety, 2022 - Elsevier
Air pollution remains one of the major health threats around the world. Compared to adults,
foetuses and infants are more vulnerable to the effects of environmental toxins. Maternal …

[HTML][HTML] Prenatal air pollution exposure and placental DNA methylation changes: implications on fetal development and future disease susceptibility

T Ghazi, P Naidoo, RN Naidoo, AA Chuturgoon - Cells, 2021 - mdpi.com
The Developmental Origins of Health and Disease (DOHaD) concept postulates that in utero
exposures influence fetal programming and health in later life. Throughout pregnancy, the …

Select early-life environmental exposures and DNA methylation in the placenta

M Mortillo, CJ Marsit - Current environmental health reports, 2023 - Springer
Abstract Purpose of Review To summarize recent literature relating early-life environmental
exposures on DNA methylation in the placenta, to identify how variation in placental …

[HTML][HTML] Life-course exposure to air pollution and biological ageing in the Lothian Birth Cohort 1936

G Baranyi, IJ Deary, DL McCartney, SE Harris… - Environment …, 2022 - Elsevier
Background Exposure to air pollution is associated with a range of diseases. Biomarkers
derived from DNA methylation (DNAm) offer potential mechanistic insights into human …

[HTML][HTML] A role for gene-environment interactions in autism spectrum disorder is supported by variants in genes regulating the effects of exposure to xenobiotics

JX Santos, C Rasga, AR Marques… - Frontiers in …, 2022 - frontiersin.org
Heritability estimates support the contribution of genetics and the environment to the etiology
of Autism Spectrum Disorder (ASD), but a role for gene-environment interactions is …

[HTML][HTML] Placental transcriptomic signatures of prenatal exposure to Hydroxy-Polycyclic aromatic hydrocarbons

AG Paquette, S Lapehn, S Freije, J MacDonald… - Environment …, 2023 - Elsevier
Abstract Background Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants
originating from petrogenic and pyrogenic sources. PAH compounds can cross the placenta …

Cohort Profile: The Shanghai Maternal-Child Pairs Cohort (MCPC)

Y Gui, Y Zhao, XG Tao, W Xu, Q Yang… - International Journal …, 2024 - academic.oup.com
Numerous studies have increasingly demonstrated that the aetiology of chronic diseases,
including autism, hyperactivity, asthma, diabetes, obesity and cardiovascular diseases, can …

[HTML][HTML] Placental transcriptomic signatures of prenatal and preconceptional maternal stress

BH Baker, S Freije, JW MacDonald, TK Bammler… - Molecular …, 2024 - nature.com
Prenatal exposure to maternal psychological stress is associated with increased risk for
adverse birth and child health outcomes. Accumulating evidence suggests that …

Prenatal exposure of organophosphate esters and its trimester-specific and gender-specific effects on fetal growth

H Wang, P Wang, Q Li, J Li, L Zhang… - Environmental …, 2022 - ACS Publications
The toxicity of organophosphate esters (OPEs) on embryonic development is well noted in
animal experiments, but epidemiological studies are still lacking. This study evaluated the …